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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1 – 15 of 85 results
1

Thermo Scientific™ Pierce™ EDC, No-Weigh™ Format

Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.

Shipping Condition Wet Ice
Content And Storage Upon receipt store desiccated at -20°C.
Description EDC
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 191.7
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Spacer Arm Length 0.0 Å
PEGylated No
3

MilliporeSigma™ Calbiochem™ SATA

Reacts with primary amines to add protected sulfhydryl groups.

5

Thermo Scientific™ Mass Spectrometry Compatible Crosslinkers

Improve mass spectrometry detection of crosslinked proteins and interactions with DSPP and TBDSPP heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at -20°C protected from moisture.
Format Standard
Cleavable No
Product Type Crosslinker
Form Solid
Reactive Moiety NHS Ester
Spacer Arm Length 4.3 Å
Quantity 50 mg
Labeling Method Chemical Labeling
Crosslinker Type Homotrifunctional
Chemical Reactivity Amine-Amine
Product Line MS Reagents
PEGylated No
6

Thermo Scientific™ Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))

Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.

7

Thermo Scientific™ BS(PEG)9

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

8

Thermo Scientific™ Sulfo-LC-SPDP (sulfosuccinimidyl 6-(3'-(2-pyridyldithio)propionamido)hexanoate)

Crosslink amines to sulfhydryls with this water-soluble sulfo-NHS-ester and pyridyldithiol groups on 10-atom spacer arms to form cleavable disulfide bonds with cysteines.

9

Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 425.39
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 17.6 Å
Product Line Pierce™
PEGylated Yes
10

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

11

Thermo Scientific™ Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of a water-soluble, 8-atom (9.4A) spacer arm.

12

Thermo Scientific™ Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aromatic, 10-atom spacer arm.

13

Thermo Scientific™ BMH (bismaleimidohexane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues in proteins or peptides) with this long crosslinker composed of maleimide groups and 11-atom (13.0A) spacer arm.

14

Thermo Scientific™ DTSSP (3,3'-dithiobis(sulfosuccinimidyl propionate))

Crosslink amines to amines with Sulfo-DSP; composed of sulfo-NHS-ester groups and disulfide spacer arm (12.0A) that is cleavable with reducing agents.

15

Thermo Scientific™ BS3-d0 (bis(sulfosuccinimidyl) suberate-d0)

Crosslink amines to amines using these heavy (deuterated) and light matched pairs of an 11.4A, NHS-ester crosslinker for mass spectrometry analysis of protein interactions.