Corning™'s 3D Clear tissue clearing technique is designed specifically to support imaging for 3D cell culture models and plate-based high-throughput processing. When paired with fluorescent labeling (e.g. fluorescent protein, immunofluorescence, chemical dyes) and high content confocal microscopy, Corning™'s 3D Clear Reagent allows for complete 3D cell culture model characterization and more accurate drug screening.