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Streptozotocin, MP Biomedicals™

Used in the treatment of pancreatic islet cell tumors. Streptozotocin, MP Biomedicals is a glucosamine-nitrosourea, a DNA-alkylating agent that enters cells via the GLUT2 glucose transport protein. It is used to treat malignant insulinoma and to induce Ty

Supplier:  MP Biomedicals Inc 021005575

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Catalog No. MP21005575


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Description

Description

Streptozocin is used to treat pancreatic islet cell tumors, including malignant insulinoma. It is also used to induce Type 1 diabetes in animals for medical research purposes.

  • An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets
  • Induces death of insulin-secreting cells, producing an animal model of diabetes
  • Potent DNA methylating agent that induces chromosomal breakage
  • Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter
Specifications

Specifications

Powder
121°C (decomposition) (literature)
500 mg
N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozocin, STZ, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
ZSJLQEPLLKMAKR-UHEPRFFZSA-N
1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
45357367
∼75% α-anomer basis, ≥97%
18883-66-4
EmM (228nm): 6.36 (ethanol)
C8H15N3O7
Soluble in water (50mg/mL, clear to slightly hazy, light yellow solution) and ethanol.
CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
265.222
265.22

Chemical Identifiers

18883-66-4
265.222
N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozocin, STZ, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
C8H15N3O7
ZSJLQEPLLKMAKR-UHEPRFFZSA-N
45357367
CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
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Safety and Handling

Safety and Handling

Recommended Storage : −20°C, desiccate, store under nitrogen

SDS
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