Invitrogen™ Silencer™ Select Human Drug Targets siRNA Library 

Description

• The Silencer™ Select Human Drug Targets siRNA Library includes genes involved in apoptosis, senescence, nucleic acid binding, autophagy, DNA repair, along with characterized nuclear receptors and other genes that are considered potential targets for therapeutics
• The Silencer Select Human Drug Targets siRNA Library contains 23,778 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 7,926 genes for performing RNAi screens against known human drug target genes
• This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database
• It is cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC)
• The library includes gene IDs from Thermo Fisher's Human Druggable Genome and Human Extended Druggable Genome siRNA libraries that are not already in the kinase, phosphatase, protease, ion channel, GPCR or ubiquitin libraries
• The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading algorithms—along with our novel locked nucleic acid (LNA) chemical modifications
• This helps to help ensure the efficacy, specificity, and potency required for RNAi screening using a comprehensive pre-defined platform for therapeutic discovery
• Superior efficacy – Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency – Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable – Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient – Reduce data de-convolution and accelerate target validation with our 96- and 384-well arrayed format
• Customizable – Choose the best option for workflow demands, including additional siRNA scales and pooled formats
• Contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume)