missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Thermo Scientific Chemicals U-18666A, 95%
$184.33 - $316.77
Chemical Identifiers
| CAS | 3039-71-2 |
|---|---|
| Molecular Formula | C25H42ClNO2 |
| Synonym | 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|
AAJ67389MA
|
Thermo Scientific Chemicals
J67389MA |
10 mg |
Each for $316.77
|
|
|||||
|
AAJ67389LB0
|
Thermo Scientific Chemicals
J67389LB0 |
5 mg |
Each for $184.33
|
|
|||||
Description
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chemical Identifiers
| 3039-71-2 | |
| C25H42ClNO2 | |
| 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride |
Specifications
| 10 mg | |
| 2°C to 8°C | |
| C25H42ClNO2 | |
| 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride | |
| Soluble in water at 10mg/ml | |
| Solid | |
| [H+].[Cl-].CCN(CC)CCOC1CCC2=CCC3C4CCC(=O)C4(C)CCC3C2(C)C1 | |
| 424.07 |
| White to off-white | |
| 3039-71-2 | |
| 424.06 | |
| 195°C to 196.5°C | |
| U-18666A, 95% | |
| ICPRVJHNLABCSA-UHFFFAOYNA-N | |
| hydrogen 8-[2-(diethylamino)ethoxy]-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one chloride | |
| 95% |
Safety and Handling
Recommended Storage : Keep cold
RUO – Research Use Only