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Triphosgene, 98%
CAS: 32315-10-9 | C3Cl6O3 | 296.73 g/mol
Supplier: Thermo Scientific Chemicals A1493206
Description
Triphosgene is used as a carbonylating agent for aza-peptide synthesis. It reacts with several alfa-amino acids to give the corresponding N-carboxyanhydrides. It is involved in the preparation of the esterification coupling reagent, di-2-thienyl carbonate from 2(5H)-thiophenone. Further, it is used as a reagent in organic synthesis and converts an amino group into isocyanate. In addition to this, it is employed in the preparation of 2-chloronicotinaldehydes through cyclization of the corresponding enamides. It is considered as a useful substitute for phosgene.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTriphosgene is used as a carbonylating agent for aza-peptide synthesis. It reacts with several alfa-amino acids to give the corresponding N-carboxyanhydrides. It is involved in the preparation of the esterification coupling reagent, di-2-thienyl carbonate from 2(5H)-thiophenone. Further, it is used as a reagent in organic synthesis and converts an amino group into isocyanate. In addition to this, it is employed in the preparation of 2-chloronicotinaldehydes through cyclization of the corresponding enamides. It is considered as a useful substitute for phosgene.
Solubility
Soluble in ether, ethanol, tetrahydrofuran, benzene, cyclohexane, chloroform, hexane, carbon tetrachloride, dichloromethane and chlorobenzene. Insoluble in water.
Notes
Moisture sensitive. Store in a cool place. Incompatible with oxidizing agents.
Specifications
| Triphosgene | |
| 77°C to 91°C | |
| 203°C to 206°C | |
| MFCD00062848 | |
| UN2928 | |
| Moisture sensitive | |
| Soluble in ether,ethanol,tetrahydrofuran,benzene,cyclohexane,chloroform,hexane,carbon tetrachloride,dichloromethane and chlorobenzene. Insoluble in water. | |
| C(=O)(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | |
| 296.73 | |
| 296.75 |
| 32315-10-9 | |
| 1.6 | |
| C3Cl6O3 | |
| 5 g | |
| 1787583 | |
| triphosgene, bis trichloromethyl carbonate, methanol, trichloro-, carbonate 2:1, ditrichloromethyl carbonate, triphosgene bis-trichloromethyl carbonate, methanol, 1,1,1-trichloro-, 1,1'-carbonate, triphosgen, tri phosgene, tri-phosgene | |
| UCPYLLCMEDAXFR-UHFFFAOYSA-N | |
| bis(trichloromethyl) carbonate | |
| 94429 | |
| 98% |
Chemical Identifiers
| 32315-10-9 | |
| 296.73 | |
| UCPYLLCMEDAXFR-UHFFFAOYSA-N | |
| 94429 | |
| C(=O)(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl |
| C3Cl6O3 | |
| MFCD00062848 | |
| triphosgene, bis trichloromethyl carbonate, methanol, trichloro-, carbonate 2:1, ditrichloromethyl carbonate, triphosgene bis-trichloromethyl carbonate, methanol, 1,1,1-trichloro-, 1,1'-carbonate, triphosgen, tri phosgene, tri-phosgene | |
| bis(trichloromethyl) carbonate |
Safety and Handling
GHS H Statement
H330-H314-H318
Fatal if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
P260-P264b-P271-P280-P284-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
H314-H330-H335
DOTInformation : Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, CORROSIVE, ORGANIC, N.O.S.
EINECSNumber : 250-986-3
TSCA : Yes
Recommended Storage : Keep cold; Store under Argon
RUO – Research Use Only