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Tamibarotene
A retinoic acid receptor → (RAR→) agonist | CAS: 94497-51-5 | C22H25NO3 | 351.45 g/mol
$277.40 - $1016.52
Chemical Identifiers
| CAS | 94497-51-5 |
|---|---|
| Molecular Formula | C22H25NO3 |
| Molecular Weight (g/mol) | 351.45 |
| MDL Number | MFCD00866188 |
| InChI Key | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
| Synonym | tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 |
| PubChem CID | 108143 |
| ChEBI | CHEBI:32181 |
| IUPAC Name | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid |
| SMILES | CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ64028MA
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Thermo Scientific Chemicals
J64028MA |
10 mg |
Each for $277.40
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AAJ64028MF
|
Thermo Scientific Chemicals
J64028MF |
50 mg |
Each for $1,016.52
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Description
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
Solubility
Soluble to 50 mM in DMSO
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Chemical Identifiers
| 94497-51-5 | |
| 351.45 | |
| MUTNCGKQJGXKEM-UHFFFAOYSA-N | |
| 108143 | |
| 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid |
| C22H25NO3 | |
| MFCD00866188 | |
| tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 | |
| CHEBI:32181 | |
| CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 |
Specifications
| 94497-51-5 | |
| C22H25NO3 | |
| 10 mg | |
| tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 | |
| MUTNCGKQJGXKEM-UHFFFAOYSA-N | |
| 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid | |
| 108143 | |
| 351.44 | |
| Tamibarotene |
| White | |
| MFCD00866188 | |
| 14,9047 | |
| Soluble to 50 mM in DMSO | |
| CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 | |
| 351.45 | |
| CHEBI:32181 | |
| Solid |
Safety and Handling
RTECSNumber : DH6940000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only