Invitrogen™ SARS Coronavirus Spike Protein Polyclonal Antibody

Description

This antibody has been used for Flow Cytometry to detect HEK293T.17 cells transfected with vaccine-expressing membrane-bound SARS-CoV-2 spike protein. View Article The immunogen is 100% (16/16) homologous to SARS-COV-2 (COVID-19) Spike protein. The cross reactivity is not empirically tested. Suggested positive control: transfected mouse melanoma cell lysate.

It has recently been shown that SARS (severe acute respiratory syndrome) is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness, such as the common cold, in humans. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The glycosylated spike protein (as well as the nucleocapsid protein) can be detected in infected cell culture supernatants with antisera from SARS patients.