Invitrogen™ RAB11FIP1 Polyclonal Antibody

Description

Positive test controls include: HeLa, HepG2, COS-7. The target is usually found in the following locations: Cytoplasmic vesicle, Recycling endosome, phagosome membrane. Immunogen sequence: EAKGEIKDSS PSSSPSPKGF RKKHLFSSTE NLAAGSWKEP AEGGGLSSDR QLSESSTKDS LKSMTLPSYR PAPLVSGDLR ENMAPANSEA TKEAKESKKP ESRRSSLLSL MTGKKDVAKG SEGENPLTVP GREKEGMLMG VKPGEDASGP AEDLVRRSEK DTAAVVSRQG SSLNLFEDVQ ITEPEAEPES KSEPRPPISS PRAPQTRAVK P.

Rab11-FIP1 (Rab 11 family-interacting protein 1), also known as Rab-coupling protein (RCP), is a 1283 amino acid Rab 11 effector protein. Rab11-FIP1, by interacting with Rab GTPases, is involved in the endosomal recycling process and may play a role in controlling membrane trafficking along the phagocytic pathway and during phagocytosis. Localized to the recycling endosome, the cytoplasmic membrane and phagosome membranes, Rab11-FIP1 is expressed as five isoforms produced by alternative splicing. As the most highly expressed isoform, isoform two of Rab11-FIP1 is expressed in brain, lung, testis, small intestine, spleen and heart. Isoform two of Rab11-FIP1 also has been found to form a homooligomer and is believed to interact with many Rab GTPases, including Rab 4A, Rab 11A, Rab 11B and Rab 25.