Invitrogen™ PPP1R9B Monoclonal Antibody (K94019_12A3), Invitrogen™

Description

Sequence of this protein is as follows: FSTAPIQVFS TYSNEDYDRR NEDVDPMAAS AEYELEKRVE RLELFPVELE KDSEGLGISI IGMGAGADMG LEKLGIFVKT VTEGGAAHRD GRIQVNDLLV EVDGTSLVGV TQSFAASVLR NTKGRVRFMI GRERPGEQSE VAQLIQQTLE QERWQREMME QRYAQYGEDD EETGEYATDE DEELSPTFPG GEMAIEVFEL AENEDALSPV DMEPEKLVHK FKELQIKHAV TEAEIQQLKR KLQSLEQEKG RWRVEKAQLE QSVEENKERM EKLEGYWGEA QSLCQAVDEH LRETQAQYQA LERKYSKAKR LIKDYQQKEI EFLKKETAQR RVLEESELAR KEEMDKLLDK ISELEGNLQT

Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.