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Necrostatin-1
CAS: 4311-88-0 | C13H13N3OS | 259.327 g/mol
Supplier: Thermo Scientific Chemicals J65341FPL
Description
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsNecrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe
Specifications
| Necrostatin-1 | |
| Yellow | |
| MFCD00056916 | |
| Light sensitive | |
| Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml). | |
| CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 | |
| 259.327 | |
| 259.33 |
| 4311-88-0 | |
| C13H13N3OS | |
| 20 mg | |
| necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo | |
| TXUWMXQFNYDOEZ-UHFFFAOYSA-N | |
| 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one | |
| 2828334 | |
| Powder |
Chemical Identifiers
| 4311-88-0 | |
| 259.327 | |
| TXUWMXQFNYDOEZ-UHFFFAOYSA-N | |
| 2828334 | |
| CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
| C13H13N3OS | |
| MFCD00056916 | |
| necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo | |
| 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one |
Safety and Handling
TSCA : No
storageNote1 : 2° to 8°C
Recommended Storage : Keep cold
RUO – Research Use Only