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Mevastatin, 98%
CAS: 73573-88-3 | C23H34O5 | 390.52 g/mol
Supplier: Thermo Scientific Chemicals J61357LB0
Description
Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsMevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.
Solubility
Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C
Specifications
| Mevastatin | |
| White | |
| MFCD05662341 | |
| 1269441 | |
| mevastatin, compactin, mevastatinum, mevastatina, mevastatine, mevastatinum inn-latin, antibiotic ml 236b, mevastatin inn, compactin penicillium, mevastatine inn-french | |
| AJLFOPYRIVGYMJ-INTXDZFKSA-N | |
| [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate | |
| 64715 | |
| 390.52 | |
| Crystalline Solid |
| 73573-88-3 | |
| C23H34O5 | |
| 5 mg | |
| 14,6164 | |
| Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml | |
| CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 | |
| 390.52 | |
| CHEBI:34848 | |
| 98% |
Chemical Identifiers
| 73573-88-3 | |
| 390.52 | |
| AJLFOPYRIVGYMJ-INTXDZFKSA-N | |
| 64715 | |
| [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
| C23H34O5 | |
| MFCD05662341 | |
| mevastatin, compactin, mevastatinum, mevastatina, mevastatine, mevastatinum inn-latin, antibiotic ml 236b, mevastatin inn, compactin penicillium, mevastatine inn-french | |
| CHEBI:34848 | |
| CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 |
Safety and Handling
RTECSNumber : EK7907100
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only