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L(+)-Amethopterin hydrate, 99%
L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol
Supplier: Thermo Scientific Chemicals 208101000
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
- It has tumoricidal activity
Applications
- L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
- It can be used in anti-tumor studies
- It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
- It can also inhibit production of pro-inflammatory cytokines
Specifications
| L(+)-Amethopterin hydrate | |
| 195°C | |
| Authentic | |
| Glass Bottle | |
| MFCD00150847 | |
| 14, 5985 | |
| l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate | |
| FBOZXECLQNJBKD-UGPWUYPHNA-N | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate | |
| 45157423 | |
| 99% |
| 133073-73-1 | |
| Yellow to Orange | |
| 98.5% min. (HPLC) | |
| C20H22N8O5 | |
| 100 mg | |
| + 21.5 | |
| Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a | |
| CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O | |
| 454.45 | |
| 454.44 | |
| Crystalline Powder |
Chemical Identifiers
| 133073-73-1 | |
| 454.45 | |
| FBOZXECLQNJBKD-UGPWUYPHNA-N | |
| 45157423 | |
| CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| C20H22N8O5 | |
| MFCD00150847 | |
| l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate | |
| (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate |
Safety and Handling
GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.
GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
GHS Signal Word: Danger
RUO – Research Use Only