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MilliporeSigma™ TPC-1 Human Papillary Thyroid Carcinoma Cell Line

TPC-1 is a widely published and well-characterized cell line isolated from a papillary thyroid carcinoma of a female patient

Supplier: MilliporeSigma™ SCC147

Catalog No. SCC147

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Description

The genome of TPC-1 contains the RET/PTC1 rearrangement found in approximately 20% of sporadic papillary carcinomas in adults
TPC-1 harbors a silent polymorphism in H-RAS, and is wild-type for sequences of BRAF, CNBB1, EGFR, K-RAS, RAF-1, PI3K, and TRHB
TPC-1 cells produce thyroglobulin (Tg) as well as expressing the thyroid differentiation marker PAX8 and the tumor progression factor podoplanin
TPC-1 has been utilized as an in vitro model for human cytomegalovirus latency, a potential contributor for certain human cancers
The TPC-1 cell line is thus an excellent system for investigating mechanisms of thyroid carcinogenesis

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