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Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade
A protein denaturant | CAS: 50-01-1 | CH6ClN3 | 95.53 g/mol
Supplier: Thermo Scientific Chemicals J6566136
Description
Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsGuanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Solubility
Freely soluble in water
Notes
Protect from heat. Store away from oxidizing agents.
Specifications
| Guanidine hydrochloride | |
| 178°C to 185°C | |
| 1.34 | |
| MFCD00013026 | |
| 3591990 | |
| 144562 | |
| Freely soluble in water | |
| C(=N)(N)N.Cl | |
| 95.53 | |
| CHEBI:32735 | |
| Molecular Biology |
| 50-01-1 | |
| White | |
| CH6ClN3 | |
| 500 g | |
| Hygroscopic | |
| guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride | |
| PJJJBBJSCAKJQF-UHFFFAOYSA-N | |
| guanidine;hydrochloride | |
| 5742 | |
| 95.53 | |
| Crystalline Solid |
Chemical Identifiers
| 50-01-1 | |
| 95.53 | |
| PJJJBBJSCAKJQF-UHFFFAOYSA-N | |
| 5742 | |
| guanidine;hydrochloride |
| CH6ClN3 | |
| MFCD00013026 | |
| guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride | |
| CHEBI:32735 | |
| C(=N)(N)N.Cl |
Safety and Handling
Causes serious eye irritation, May form combustible dust concentrations in air, Causes skin irritation, Harmful if swallowed or if inhaled
Serious eye damage/eye irritation (category 2), Skin corrosion/irritation (category 2), Acute toxicity (category 4)
EINECSNumber : 200-002-3
RTECSNumber : MF4300000
TSCA : Yes
Recommended Storage : Ambient temperatures
RUO – Research Use Only