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  9. 4009500

GSK 269962, Tocris Bioscience™ DFS Item

Potent and selective ROCK inhibitor

Supplier:  Thermo Fisher Scientific 400950

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Catalog No. 4009500


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Description

Description

Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension.
Specifications

Specifications

GSK 269962
C29H30N8O5
aminofurazanyl-azabenzimidazole 6n, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-morpholin-4-yl ethoxy benzamide, kinome_3843, d02zqs, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-4-morpholinyl ethoxy benzamide, n-3-2-4-amino-furazan-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-4-morpholinyl ethyl oxy benzamide, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethylimidazo 5,4-d pyridin-6-yl oxyphenyl-4-2-morpholin-4-ylethoxy benzamide
CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6
570.61
570.6
850664-21-0
50 mg
YOVNFNXUCOWYSG-UHFFFAOYSA-N
N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide
16095342
>99%

Chemical Identifiers

850664-21-0
570.61
aminofurazanyl-azabenzimidazole 6n, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-morpholin-4-yl ethoxy benzamide, kinome_3843, d02zqs, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-4-morpholinyl ethoxy benzamide, n-3-2-4-amino-furazan-3-yl-1-ethyl-1h-imidazo 4,5-c pyridin-6-yl oxy phenyl-4-2-4-morpholinyl ethyl oxy benzamide, n-3-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethylimidazo 5,4-d pyridin-6-yl oxyphenyl-4-2-morpholin-4-ylethoxy benzamide
N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide
C29H30N8O5
YOVNFNXUCOWYSG-UHFFFAOYSA-N
16095342
CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6
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Recommended Storage : Store at +4°C

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