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FOXP3 Monoclonal Antibody (236A/E7), Alexa Fluor™ Plus 647, Invitrogen™
Mouse Monoclonal Antibody
Supplier: Fisher Chemical 756477782
Description
Description: The PCH101 antibody reacts with the amino terminus of human foxp3 protein also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. Intracellular staining of human peripheral blood mononuclear cells (PBMCs) with PCH101 antibody using the anti-human Foxp3 Staining Set and protocol reveals approximately 0.5-4% of lymphocytes staining, with the majority of staining occurring in the CD25^bright population. This is subject to donor variability. PCH101 crossreacts with rhesus, chimpanzee and cynomolgus. This PCH101 antibody has been reported for use in immunoblotting (WB) and immunohistology on frozen and paraffin-embedded tissue sections. This PCH101 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using high pH antigen retrieval and can be used at 20 μg/mL.
FOXP3 Monoclonal antibody specifically detects FOXP3 in Human samples. It is validated for Immunohistochemistry (Paraffin)Specifications
| FOXP3 | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.5% BSA, 10% proprietary stabilizer and 0.05% sodium azide; pH 7.2 | |
| Q9BZS1 | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Immunohistochemistry (Paraffin) | |
| 236A/E7 | |
| Alexa Fluor Plus 647 | |
| Foxp3 | |
| AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID | |
| Affinity chromatography | |
| RUO | |
| 50943 | |
| 4° C, store in dark | |
| Liquid |