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Doxepin hydrochloride
Potent H1-histamine receptor antagonist and a 5-HT receptor antagonist | CAS: 1229-29-4 | C19H22ClNO | 315.841 g/mol
$75.38 - $1170.40
Chemical Identifiers
| CAS | 1229-29-4 |
|---|---|
| Molecular Formula | C19H22ClNO |
| Molecular Weight (g/mol) | 315.841 |
| MDL Number | MFCD00079135 |
| InChI Key | MHNSPTUQQIYJOT-SJDTYFKWSA-N |
| Synonym | doxepin hydrochloride, novoxapin, aponal, toruan, curatin, sinequan, zonalon, adapin, doxepine hydrochloride, novoxapin hydrochloride |
| PubChem CID | 6419921 |
| IUPAC Name | (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ6257903
|
Thermo Scientific Chemicals
J6257903 |
1 g |
Each for $75.38
|
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AAJ6257906
|
Thermo Scientific Chemicals
J6257906 |
5 g |
Each for $268.33
|
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|
AAJ6257914
|
Thermo Scientific Chemicals
J6257914 |
25 g |
Each for $1,170.40
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Description
It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilitySoluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Chemical Identifiers
| 1229-29-4 | |
| 315.841 | |
| MHNSPTUQQIYJOT-SJDTYFKWSA-N | |
| 6419921 | |
| CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl |
| C19H22ClNO | |
| MFCD00079135 | |
| doxepin hydrochloride, novoxapin, aponal, toruan, curatin, sinequan, zonalon, adapin, doxepine hydrochloride, novoxapin hydrochloride | |
| (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride |
Specifications
| 1229-29-4 | |
| White | |
| MFCD00079135 | |
| UN2811 | |
| doxepin hydrochloride, novoxapin, aponal, toruan, curatin, sinequan, zonalon, adapin, doxepine hydrochloride, novoxapin hydrochloride | |
| MHNSPTUQQIYJOT-SJDTYFKWSA-N | |
| (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride | |
| 6419921 | |
| Powder |
| 187°C to 189°C | |
| C19H22ClNO | |
| 1 g | |
| 14,3435 | |
| Soluble in water (100 mM),chloroform (1:2),alcohol (1:1),methanol,and DMSO. | |
| CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl | |
| 315.841 | |
| 315.84 | |
| Doxepin hydrochloride |
Safety and Handling
GHS H Statement
H301-H361
Toxic if swallowed.
Suspected of damaging fertility or the unborn child.
P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
H301-H361
DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber : 214-966-8
RTECSNumber : HQ4375000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only