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Cytarabine, 98%
Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent. | CAS: 147-94-4 | C9H13N3O5 | 243.22 g/mol
Supplier: Thermo Scientific Chemicals 449561000
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Cytarabine is a nucleoside analog that acts as an antileukemic agent
- Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
- Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
- Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
- Useful for laboratory studies of cytarabine resistance mechanisms
- At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
- It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
Specifications
| Cytarabine | |
| 220.0°C | |
| Glass bottle | |
| 100 mg | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
| 6253 | |
| 243.22 |
| 147-94-4 | |
| 97.5% min. (HPLC) | |
| C9H13N3O5 | |
| 152781 | |
| Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O | |
| 243.22 | |
| CHEBI:28680 | |
| 98% |
Chemical Identifiers
| 147-94-4 | |
| 243.22 | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| CHEBI:28680 | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| C9H13N3O5 | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 6253 | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Safety and Handling
Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction
Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)
EINECSNumber : 205-705-9
RUO – Research Use Only