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CGS 21680 hydrochloride, 99%
An A2A Adenosine receptor agonist | CAS: 120225-54-9 | C23H30ClN7O6 | 535.986 g/mol
Supplier: Thermo Scientific Chemicals J60793MA
Description
CGS 21680 hydrochloride is currently used in research in studying neuronal transmission, also in respiration. CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues. CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsCGS 21680 hydrochloride is currently used in research in studying neuronal transmission, also in respiration. CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues. CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity.
Solubility
Soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Specifications
| CGS 21680 hydrochloride | |
| White | |
| MFCD11045878 | |
| cgs-21680 hydrochloride hydrate, 3-4-2-6-amino-9-2r,3r,4s,5s-5-ethylcarbamoyl-3,4-dihydroxyoxolan-2-yl purin-2-yl amino ethyl phenyl propanoic acid hydrate hydrochloride, c23h29n7o6.clh.h2o, cgs-21680 hydrochloride hydrate, solid, 2-p-2-carboxyethyl phenethylamino-5 inverted exclamation marka-n-ethylcarboxamidoadenosine hydrochloride hydrate | |
| QPHVMNOEKKJYJO-XWOZMEDYSA-N | |
| 3-[4-[2-[[6-amino-9-[(2S,4S,5R)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride | |
| 133639586 | |
| 99% |
| 120225-54-9 | |
| C23H30ClN7O6 | |
| 10 mg | |
| Soluble up to 3.4mg/mL in DMSO and 20mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin. | |
| CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O.Cl | |
| 535.986 | |
| 535.98 | |
| Solid |
Chemical Identifiers
| 120225-54-9 | |
| 535.986 | |
| QPHVMNOEKKJYJO-XWOZMEDYSA-N | |
| 133639586 | |
| CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O.Cl |
| C23H30ClN7O6 | |
| MFCD11045878 | |
| cgs-21680 hydrochloride hydrate, 3-4-2-6-amino-9-2r,3r,4s,5s-5-ethylcarbamoyl-3,4-dihydroxyoxolan-2-yl purin-2-yl amino ethyl phenyl propanoic acid hydrate hydrochloride, c23h29n7o6.clh.h2o, cgs-21680 hydrochloride hydrate, solid, 2-p-2-carboxyethyl phenethylamino-5 inverted exclamation marka-n-ethylcarboxamidoadenosine hydrochloride hydrate | |
| 3-[4-[2-[[6-amino-9-[(2S,4S,5R)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid;hydrochloride |
Safety and Handling
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only