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Amlodipine besylate, 98+%
An L-type calcium channel antagonist with potent antioxidant activity | CAS: 111470-99-6 | C26H31ClN2O8S | 567.05 g/mol
$216.55 - $1084.53
Chemical Identifiers
| CAS | 111470-99-6 |
|---|---|
| Molecular Formula | C26H31ClN2O8S |
| Molecular Weight (g/mol) | 567.05 |
| MDL Number | MFCD00887594 |
| InChI Key | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| Synonym | amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin |
| PubChem CID | 60496 |
| ChEBI | CHEBI:2669 |
| IUPAC Name | benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O |
| Catalog Number | Mfr. No. | Quantity | Price | Qty | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Qty | |||||
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AAJ6216403
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Thermo Scientific Chemicals
J6216403 |
1 g |
Each for $216.55
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AAJ6216406
|
Thermo Scientific Chemicals
J6216406 |
5 g |
Each for $429.52
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AAJ6216414
|
Thermo Scientific Chemicals
J6216414 |
25 g |
Each for $1,084.53
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Description
Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsAmlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
Solubility
Soluble in DMSO (≥20 mg/mL), water (10 mM), chloroform, ethanol (≥14 mg/mL), and methanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Chemical Identifiers
| 111470-99-6 | |
| 567.05 | |
| ZPBWCRDSRKPIDG-UHFFFAOYSA-N | |
| 60496 | |
| benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| C26H31ClN2O8S | |
| MFCD00887594 | |
| amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin | |
| CHEBI:2669 | |
| CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O |
Specifications
| 111470-99-6 | |
| White | |
| MFCD00887594 | |
| 14,491 | |
| Soluble in DMSO (?20mg/mL),water (10 mM),chloroform,ethanol (?14mg/mL),and methanol. | |
| CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O | |
| 567.05 | |
| CHEBI:2669 | |
| ≥98% | |
| Amlodipine besylate |
| 195°C to 204°C | |
| C26H31ClN2O8S | |
| 1 g | |
| amlodipine besylate, amlodipine besilate, cardiorex, amlodipine benzenesulfonate, istin, amdepin, amdipin, amlodin, amlogard, amlopin | |
| ZPBWCRDSRKPIDG-UHFFFAOYSA-N | |
| benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | |
| 60496 | |
| 567.05 | |
| Solid |
Safety and Handling
GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
H302-H315-H319-H335
RTECSNumber : US7967700
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only