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Amiloride hydrochloride dihydrate
Sodium channel blocker | CAS: 17440-83-4 | C6H13Cl2N7O3 | 302.116 g/mol
Supplier: Thermo Scientific Chemicals J6216806
Description
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride
- HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsAmiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Solubility
Soluble in water at 50mg/ml
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Specifications
| Amiloride hydrochloride dihydrate | |
| >240°C | |
| C6H13Cl2N7O3 | |
| 5 g | |
| 14,406 | |
| Soluble in water at 50mg/ml | |
| C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl | |
| 302.116 | |
| CHEBI:2640 | |
| Powder |
| 17440-83-4 | |
| Yellow | |
| MFCD00058197 | |
| UN2811 | |
| amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate | |
| LTKVFMLMEYCWMK-UHFFFAOYSA-N | |
| 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride | |
| 68540 | |
| 266.09 |
Chemical Identifiers
| 17440-83-4 | |
| 302.116 | |
| LTKVFMLMEYCWMK-UHFFFAOYSA-N | |
| 68540 | |
| 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride |
| C6H13Cl2N7O3 | |
| MFCD00058197 | |
| amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate | |
| CHEBI:2640 | |
| C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl |
Safety and Handling
GHS H Statement
H301
Toxic if swallowed.
P264b-P270-P301+P310-P330-P501c
H301
DOTInformation : Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber : 217-958-2
RTECSNumber : UQ2275500
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only