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4-Nitrobenzenesulfonyl chloride, 97%
CAS: 98-74-8 | C6H4ClNO4S | 221.61 g/mol
$132.56 - $1279.85
Chemical Identifiers
| CAS | 98-74-8 |
|---|---|
| Molecular Formula | C6H4ClNO4S |
| Molecular Weight (g/mol) | 221.61 |
| MDL Number | MFCD00007445 |
| InChI Key | JXRGUPLJCCDGKG-UHFFFAOYSA-N |
| Synonym | 4-nitrobenzenesulfonylchloride, 4-nitrobenzene-1-sulfonyl chloride, benzenesulfonyl chloride, 4-nitro, 4-nitrobenzenesulphonyl chloride, 4-nitrophenylsulfonyl chloride, p-nitrophenylsulfonyl chloride, 4-nitrobenzenesulfonic acid chloride, p-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulphonylchloride, 4-nitro-benzenesulfonyl chloride |
| PubChem CID | 7404 |
| SMILES | [O-][N+](=O)C1=CC=C(C=C1)S(Cl)(=O)=O |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAA1851214
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Thermo Scientific Chemicals
A1851214 |
25 g |
Each for $132.56
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AAA1851222
|
Thermo Scientific Chemicals
A1851222 |
100 g |
Each for $323.05
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AAA1851236
|
Thermo Scientific Chemicals
A1851236 |
500 g |
Each for $1,279.85
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Description
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate).
Solubility
Soluble in toluene, tetrahydrofuran, methylene chloride and ethyl acetate. Insoluble in water.
Notes
Moisture sensitive. Incompatible with strong oxidizing agents and strong bases.
Chemical Identifiers
| 98-74-8 | |
| 221.61 | |
| JXRGUPLJCCDGKG-UHFFFAOYSA-N | |
| 7404 |
| C6H4ClNO4S | |
| MFCD00007445 | |
| 4-nitrobenzenesulfonylchloride, 4-nitrobenzene-1-sulfonyl chloride, benzenesulfonyl chloride, 4-nitro, 4-nitrobenzenesulphonyl chloride, 4-nitrophenylsulfonyl chloride, p-nitrophenylsulfonyl chloride, 4-nitrobenzenesulfonic acid chloride, p-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulphonylchloride, 4-nitro-benzenesulfonyl chloride | |
| [O-][N+](=O)C1=CC=C(C=C1)S(Cl)(=O)=O |
Specifications
| 98-74-8 | |
| 143°C to 144°C (1.5 mmHg) | |
| MFCD00007445 | |
| UN3261 | |
| Moisture sensitive | |
| Soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water. | |
| [O-][N+](=O)C1=CC=C(C=C1)S(Cl)(=O)=O | |
| 221.61 | |
| 221.62 | |
| 4-Nitrobenzenesulfonyl chloride |
| 76°C to 80°C | |
| C6H4ClNO4S | |
| 25 g | |
| 746543 | |
| 4-nitrobenzenesulfonylchloride, 4-nitrobenzene-1-sulfonyl chloride, benzenesulfonyl chloride, 4-nitro, 4-nitrobenzenesulphonyl chloride, 4-nitrophenylsulfonyl chloride, p-nitrophenylsulfonyl chloride, 4-nitrobenzenesulfonic acid chloride, p-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulphonylchloride, 4-nitro-benzenesulfonyl chloride | |
| JXRGUPLJCCDGKG-UHFFFAOYSA-N | |
| 4-nitrobenzenesulfonyl chloride | |
| 7404 | |
| 97% |
Safety and Handling
GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.
P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
H314
DOTInformation : Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber : 202-697-9
TSCA : Yes
Recommended Storage : Ambient temperatures; Store under Nitrogen
RUO – Research Use Only