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2,2,2-Trifluoroethanol, 99+%
CAS: 75-89-8 | C2H3F3O | 100.04 g/mol
Supplier: Thermo Scientific Chemicals A1078818
Description
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTrifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.
Solubility
Miscible with water, ethers, ketones, alcohols and chloroform.
Notes
Moisture sensitive.
Specifications
| 2,2,2-Trifluoroethanol | |
| -44°C | |
| 74°C to 75°C | |
| C2H3F3O | |
| CF3CH2OH | |
| 50 g | |
| 1733203 | |
| Miscible with water,ethers,ketones,alcohols and chloroform. | |
| OCC(F)(F)F | |
| 100.04 | |
| CHEBI:42330 | |
| ≥99% |
| 75-89-8 | |
| 1.391 | |
| 29°C (84°F) | |
| 1.29 | |
| MFCD00004672 | |
| UN1992 | |
| trifluoroethanol, ethanol, 2,2,2-trifluoro, 2,2,2-trifluoroethan-1-ol, fluorinol 85, 2,2,2-trifluoroethyl alcohol, trifluoroethyl alcohol, trifluoro ethanol, tfe, perfluoro-1,1-dihydroethanol, tfetoh | |
| RHQDFWAXVIIEBN-UHFFFAOYSA-N | |
| 2,2,2-trifluoroethan-1-ol | |
| 6409 | |
| 100.04 |
Chemical Identifiers
| 75-89-8 | |
| 100.04 | |
| RHQDFWAXVIIEBN-UHFFFAOYSA-N | |
| 6409 | |
| OCC(F)(F)F |
| C2H3F3O | |
| MFCD00004672 | |
| trifluoroethanol, ethanol, 2,2,2-trifluoro, 2,2,2-trifluoroethan-1-ol, fluorinol 85, 2,2,2-trifluoroethyl alcohol, trifluoroethyl alcohol, trifluoro ethanol, tfe, perfluoro-1,1-dihydroethanol, tfetoh | |
| CHEBI:42330 |
Safety and Handling
GHS H Statement
H301-H311-H318-H226-H332-H315-H335
Toxic if swallowed.
Toxic in contact with skin.
Causes serious eye damage.
Flammable liquid and vapor.
Harmful if inhaled.
Causes skin irritation.
May cause respiratory irritation.
P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P311-P330-P370+P378q-P501c
H226-H301+H331-H318-H360F-H373
DOTInformation : Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
EINECSNumber : 200-913-6
RTECSNumber : KM5250000
TSCA : Yes
Recommended Storage : Ambient temperatures
RUO – Research Use Only